Small silencing RNA Biology and Mechanism

List of participants

Christophe Antoniewski (organizer), Julius Brennecke, Jérôme Cavaillé, Helge Groshans, René Ketting, Eric C. Lai, Ruth Lehmann, Allison Mallory, Danesh Moazed, Alain Pélisson, Ramesh Pillai, Carla Saleh, Hervé Seitz, Martine Simonelig, Mikiko Siomi, William Theurkauf, Yukihide Tomari, Olivier Voinnet, Phillip Zamore (organizer)

Hervé Seitz Christophe Antoniewski Julius Brennecke Olivier Voinnet William Theurkauf Phillip Zamore Alain Pélisson Martine Simonelig Jérôme Cavaillé Ramesh Pillai Mikiko Siomi Ruth Lehmann Helge Groshans Eric C. Lai René Ketting Allison Mallory Yukihide Tomari Carla Saleh Danesh Moazed Small silencing RNA biology and mechanism - Fondation des Treilles - siRNA, miRNA, piRNA, transposon, RNA silencing


Small silencing RNA Biology and Mechanism
by Christophe Antoniewski and Phillip Zamore
23 – 28 April 2012

Fifteen to 30 nucleotide-long RNAs lie at the core of a vast silencing network in animals and plants. These small silencing RNAs bind to a member of the Argonaute family of proteins to form RNA-induced silencing complexes (RISC), which they guide to complementary targets. Small RNA-directed silencing may occur by cleavage, destabilization or inhibition of translation of RNA transcripts, or by DNA or histone modification at complementary loci. Small RNAs regulate many essential biological processes, from cell differentiation and reprogramming to defense against exogenous pathogens and endogenous transposons, and even modulate chromatin dynamics. The meeting gathered 19 scientists in the opulent and collegial environment of the Les Treilles estate to discuss recent developments in understanding the biogenesis, mechanisms of action and function of the three major classes of small RNAs: microRNAs (miRNAs), small interfering RNAs (siRNAs), and Piwi-interacting RNAs (piRNAs). The presentations emphasized the high level of conservation of RNA silencing mechanisms from plants to higher vertebrates as well as the growing body of evidence for epigenetic roles of small RNAs. A final round table allowed discussing the quality requirements for deep-sequencing approaches as well as the statistical methods to use for sequence dataset analyses. All participants have agreed that the meeting was incredibly fruitful and provided a unique opportunity to establish strong relationships between the research teams

Keywords: small RNA silencing, transposon repression, siRNAs, miRNAs, piRNAs, Argonautes, heterochromatin

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