Michèle Allouche, Clara V. Alvarez, Yves-Alain Barde, Graham Barrett, Agnès Bernet, Dale E. Bredesen (organizer), Marie Castets, Céline Delloye-Bourgeois, Joanna Fombonne, Varghese John, Noriaki Kitamura, Daniel Liebl, Fanny Mann, Patrick Mehlen (organizer), Yoshinori Murakami, Akira Nakagawara, Dwayne Stupack, Masahide Takahashi, Servane Tauszig-Delamasure, David Tulasne, Ye Keqiang
4th Dependence Receptor meeting: from basic research to drug development
by Patrick Mehlen1* and Dale E. Bredesen2, 3*
22 – 27 March, 2010
2 Buck Institute for Age Research, Novato, CA 94945, USA.
3 University of California, San Francisco, San Francisco, CA 94143, USA.
Abstract: The fourth meeting on dependence receptors featured descriptions of previously unknown dependence receptors. New mechanistic data were presented on the switch between the trophic, antiapoptotic response with the proapoptotic response that occurs with loss of trophic support. The possibility that the loss of trophic support may also involve the binding of an active antitrophin was also discussed. New in vivo data were presented on the roles of dependence receptors in development, angiogenesis, oncogenesis, and neurodegeneration, as well as new therapeutic approaches based on dependence receptor function. The next meeting on dependence receptors is scheduled for 2012.